Description

2-Hydroxy-5-Trifluoromethyl-Nicotinonitrile is a high-value, multi-functional chemical intermediate characterized by its unique trifluoromethyl and cyano-substituted pyridine core. This compound is essential for the synthesis of advanced molecules, offering significant advantages in modulating the physicochemical and biological properties of target compounds. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized ligands and organic frameworks in the development of specialty polymers and advanced materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring novel heterocyclic chemistry and creating compound libraries for screening.
• Liquid Crystal & OLED Materials: Investigated as a potential intermediate for electronic materials due to its rigid, polarizable structure.

Basic Information

Product Name	2-Hydroxy-5-Trifluoromethyl-Nicotinonitrile
CAS No.	124432-69-5
Molecular Formula	C7H3F3N2O
Molecular Weight	188.11 g/mol
Synonyms	5-(Trifluoromethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 2-Hydroxy-5-(trifluoromethyl)nicotinonitrile; 3-Cyano-5-(trifluoromethyl)-2(1H)-pyridinone; 2-Hydroxy-5-(trifluoromethyl)-3-pyridinecarbonitrile; 5-Trifluoromethyl-2-hydroxynicotinonitrile; 2-Oxo-5-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-Trifluoromethyl-Nicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.