Description

4-Chloro-8-Fluoroquinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique halogenated quinazoline core serves as a critical precursor for constructing complex molecules with targeted biological activity. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors and other small-molecule therapeutics targeting cancer and inflammatory diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides and fungicides, leveraging the bioactive quinazoline scaffold.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for creating chemical probes and tool compounds to study enzyme function and cellular pathways.
• Material Science: A potential building block for organic electronic materials and photoactive compounds due to its conjugated aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and advanced intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	4-Chloro-8-Fluoroquinazoline
CAS No.	124429-27-2
Molecular Formula	C8H4ClFN2
Molecular Weight	182.58 g/mol
Synonyms	8-Fluoro-4-chloroquinazoline; 4-Chloro-8-fluoro-quinazoline; Quinazoline, 4-chloro-8-fluoro-; 124429-27-2; 4-Chlor-8-fluorchinazolin (German); 4-クロロ-8-フルオロキナゾリン (Japanese); 4-氯-8-氟喹唑啉 (Chinese)
EINECS	Contact for details

Quality Control

Our 4-Chloro-8-Fluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.