Description

1-(2-Trifluoromethyl-Phenyl)-Cyclopropanecarbonitrile is a high-value, fluorinated organic building block characterized by its cyclopropane and benzonitrile structure. This compound matters as a critical synthetic intermediate, enabling the introduction of the rigid cyclopropane ring and the versatile nitrile functional group into complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the stability imparted by the cyclopropane ring.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Acts as a monomer or building block for developing polymers and advanced organic materials with specific electronic or structural properties.
• Fluorine Chemistry Studies: Utilized in academic and industrial research to explore the effects of the trifluoromethyl group on reactivity and physicochemical properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring this unique fluorinated scaffold.

Basic Information

Product Name	1-(2-Trifluoromethyl-Phenyl)-Cyclopropanecarbonitrile
CAS No.	124276-63-7
Molecular Formula	C11H8F3N
Molecular Weight	211.18 g/mol
Synonyms	1-[2-(Trifluoromethyl)phenyl]cyclopropanecarbonitrile; α-(2-Trifluoromethylphenyl)cyclopropaneacetonitrile; 2-(Trifluoromethyl)benzenecyclopropanecarbonitrile; 1-(2-Trifluoromethylphenyl)cyclopropanecarbonitrile; (2-Trifluoromethylphenyl)cyclopropylacetonitrile; Cyclopropanecarbonitrile, 1-[2-(trifluoromethyl)phenyl]-; 1-(o-Trifluoromethylphenyl)cyclopropanecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-(2-Trifluoromethyl-Phenyl)-Cyclopropanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.