Description

7-o-(3-Amino-2,3,6-Trideoxy-2-Fluorotalopyranosyl)Daunomycinone CAS NO 124264-70-6 is a fluorinated glycosylated derivative of the anthracycline antibiotic daunomycinone, representing a key advanced intermediate in modern pharmaceutical synthesis. This compound is engineered to enhance therapeutic efficacy and reduce side effects in next-generation oncology treatments. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) focused on developing novel anticancer agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel, potent anthracycline-based chemotherapeutic agents.
• Oncology Drug Discovery: Used in research to develop new drug candidates with improved targeting and reduced cardiotoxicity profiles.
• Mechanistic Studies: Serves as a probe in biochemical research to study DNA intercalation and topoisomerase II inhibition mechanisms.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for complex glycosylated anthracyclines under GMP conditions.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory submissions in API manufacturing.

Basic Information

Product Name	7-o-(3-Amino-2,3,6-Trideoxy-2-Fluorotalopyranosyl)Daunomycinone
CAS No.	124264-70-6
Molecular Formula	C27H29FNO9
Molecular Weight	530.52 g/mol
Synonyms	2'-Fluorodaunorubicin aglycone; 7-O-(3-Amino-2,3,6-trideoxy-2-fluoro-α-L-talopyranosyl)daunomycinone; 2'-Fluoro-3'-amino-2',3',6'-trideoxytalopyranosyl daunomycinone; 2'-Fluoro-3'-amino-2',3',6'-trideoxy-α-L-talopyranosyl daunomycinone; 2'-Fluoro-3'-amino-2',3',6'-trideoxy-L-talopyranosyl daunomycinone; 7-O-(3-Amino-2,3,6-trideoxy-2-fluoro-α-L-talopyranosyl)-4-demethoxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our 7-o-(3-Amino-2,3,6-Trideoxy-2-Fluorotalopyranosyl)Daunomycinone is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC purity and structural confirmation (NMR, MS), to ensure identity, potency, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Assay (HPLC)	90.0% - 110.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.