Description

Acetylphenylalanyl-Prolyl-Bor-Arginine is a synthetic, boron-containing peptide derivative designed as a potent and selective inhibitor of proteolytic enzymes. This compound matters for researchers and developers seeking to modulate specific biological pathways, particularly those involving serine proteases like thrombin. It is primarily needed by the pharmaceutical and biotechnology sectors for applications in drug discovery, biochemical research, and the development of novel therapeutic agents targeting coagulation and inflammatory processes.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or active pharmacophore in the development of novel anticoagulant and anti-inflammatory drugs.
• Biochemical Assay Development: Used as a reference standard or inhibitor in enzymatic assays to study protease activity and inhibition kinetics.
• Protease Inhibitor Libraries: A valuable component in high-throughput screening libraries for identifying new lead compounds against specific protease targets.
• Mechanistic Studies: Employed in academic and industrial research to elucidate the role of specific proteases in disease models, such as thrombosis and cancer metastasis.
• Peptide Mimetics & Drug Design: Acts as a scaffold for designing peptide mimetics with enhanced stability and bioavailability due to the boronic acid moiety.

Basic Information

Product Name	Acetylphenylalanyl-Prolyl-Bor-Arginine
CAS No.	124216-70-2
Molecular Formula	C23H34BN7O6
Molecular Weight	515.2 g/mol
Synonyms	Ac-Phe-Pro-Boro-Arg-OH; Acetyl-Phe-Pro-Boro-Arg; Bortezomib Intermediate Analog; Boronic Acid Peptide Inhibitor; Thrombin Inhibitor Peptide; Protease Inhibitor 124216-70-2; N-Acetyl-L-phenylalanyl-N-[(1S)-1-[[(3S,6S)-6-[[(1R)-1-[(dihydroxyboranyl)amino]-4-guanidino-1-oxobutan-2-yl]carbamoyl]-2-oxo-3-piperidyl]carbamoyl]-3-methylbutyl]prolinamide
EINECS	Contact for details

Quality Control

Our Acetylphenylalanyl-Prolyl-Bor-Arginine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete batch data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.