Description

Cgs-21680 Hydrochloride is a selective adenosine A2A receptor antagonist widely used in neuroscience and pharmacological research. This compound is critical for studying the role of adenosine signaling pathways in neurological functions and disorders. It is an essential research-grade chemical for pharmaceutical R&D, academic institutions, and biotechnology companies focused on CNS drug discovery and neuropharmacology.

Application

• Neuroscience Research: A key tool compound for investigating adenosine A2A receptor function in the central nervous system.
• Pharmacological Studies: Used in in vitro and in vivo assays to elucidate receptor binding, selectivity, and downstream signaling mechanisms.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel therapeutics for Parkinson's disease, sleep disorders, and other CNS conditions.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and functional assays to identify and characterize new receptor modulators.
• Academic & Institutional Research: Fundamental for university and research institute projects exploring neuroprotection, neuroinflammation, and behavioral pharmacology.

Basic Information

Product Name	Cgs-21680 Hydrochloride
CAS No.	124182-57-6
Molecular Formula	C15H22N6O4 • HCl
Molecular Weight	378.84 g/mol
Synonyms	2-[p-(2-Carboxyethyl)phenethylamino]-5'-N-ethylcarboxamidoadenosine hydrochloride; CGS 21680 HCl; 2-[[4-[2-[[(2-Amino-9H-purin-6-yl)amino]ethyl]phenyl]ethyl]amino]-5'-N-ethylcarboxamidoadenosine hydrochloride; Adenosine A2A receptor agonist CGS 21680 hydrochloride; 5'-N-ethylcarboxamidoadenosine derivative
EINECS	Contact for details

Quality Control

Our Cgs-21680 Hydrochloride is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.