Description

Z-Pro-Leu-Ala-Nhoh is a synthetic peptide derivative containing a hydroxamic acid functional group, widely recognized by its CAS number 123984-00-9. This compound is a critical intermediate and research tool, particularly valued for its role as a potent and selective inhibitor of matrix metalloproteinases (MMPs). It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who are developing novel therapeutic agents targeting inflammation, cancer metastasis, and tissue remodeling.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of MMP inhibitor drugs.
• Biochemical Assays: Used as a potent, selective inhibitor in enzymatic studies to elucidate the role of specific MMPs in biological pathways.
• Protease Inhibition Studies: A vital tool for academic and industrial research focused on understanding extracellular matrix degradation and its implications in disease.
• Drug Discovery Screening: Employed in high-throughput screening (HTS) platforms to identify and validate new lead compounds targeting metalloproteinases.
• Bioconjugation & Peptide Chemistry: Acts as a specialized building block for synthesizing more complex peptide-based therapeutic molecules or diagnostic probes.

Basic Information

Product Name	Z-Pro-Leu-Ala-Nhoh
CAS No.	123984-00-9
Molecular Formula	C20H28N4O6
Molecular Weight	420.46 g/mol
Synonyms	Z-PLA-NHOH; N-(Benzyloxycarbonyl)-L-prolyl-L-leucyl-L-alanine hydroxamic acid; MMP Inhibitor III; MMP Inhibitor Z-Pro-Leu-Ala-NHOH; (2S)-N-[(2S)-1-[[(2S)-1-Hydroxyamino-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-(phenylmethoxycarbonyl)pyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Our Z-Pro-Leu-Ala-Nhoh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.