Description

(S)-9-(4-Methyl-1-Piperazinyl)Methyl-10-Hydroxycamptothecin is a potent, semi-synthetic derivative of the natural alkaloid camptothecin, designed for enhanced solubility and targeted activity. This compound is a critical intermediate and active pharmaceutical ingredient (API) in the development of novel topoisomerase I inhibitor-based chemotherapeutics. It is essential for pharmaceutical R&D, process chemistry, and the production of high-potency oncology drugs targeting various solid tumors.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced camptothecin analogs and prodrugs.
• Oncology Research: Used as a reference standard and active compound in preclinical studies to investigate anti-tumor mechanisms and efficacy.
• Active Pharmaceutical Ingredient (API): Employed in the formulation and manufacturing of investigational and commercial chemotherapeutic agents.
• Biochemical Tool: Utilized in biochemical assays to study topoisomerase I inhibition and DNA damage response pathways.
• Process Development: Critical for scaling up and optimizing synthetic routes for next-generation cancer therapies in pilot and commercial production.

Basic Information

Product Name	(S)-9-(4-Methyl-1-Piperazinyl)Methyl-10-Hydroxycamptothecin
CAS No.	123948-91-4
Molecular Formula	C26H26N4O5
Molecular Weight	474.51 g/mol
Synonyms	9-[(4-Methyl-1-piperazinyl)methyl]-10-hydroxy-(S)-camptothecin; (S)-9-[(4-Methylpiperazin-1-yl)methyl]-10-hydroxycamptothecin; 10-Hydroxy-9-[(4-methyl-1-piperazinyl)methyl]-(S)-camptothecin; Camptothecin derivative 9-MP-10-OH; SN-38-MP; (19S)-10-Hydroxy-9-[(4-methylpiperazin-1-yl)methyl]camptothecin
EINECS	Contact for details

Quality Control

We supply (S)-9-(4-Methyl-1-Piperazinyl)Methyl-10-Hydroxycamptothecin in high-purity grades suitable for pharmaceutical research and development. Our products undergo rigorous quality testing, including chiral purity verification and impurity profiling, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), and related substances is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the Certificate of Analysis. For long-term storage, consider storing desiccated at -20°C. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.