Description

Topotecanacetate is a key pharmaceutical intermediate and derivative of the potent topoisomerase I inhibitor, Topotecan. This compound is of significant value in the research and development of novel anticancer therapeutics, particularly for targeting solid tumors. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in oncology drug development and synthesis.

Application

• Pharmaceutical Intermediate: Critical starting material or precursor in the synthesis of Topotecan and related camptothecin analogs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate topoisomerase I inhibition mechanisms.
• Drug Discovery & Development: Serves as a building block for creating new chemical entities (NCEs) with potential antitumor activity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Topotecanacetate
CAS No.	123948-88-9
Molecular Formula	C26H27N3O6
Molecular Weight	477.51 g/mol
Synonyms	(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione acetate; Topotecan Acetate; Topotecan Acetate Salt; SKF 104864-A; NSC 609699 acetate; (S)-9-Dimethylaminomethyl-10-hydroxycamptothecin acetate; Hycamtin Acetate
EINECS	Contact for details

Quality Control

Our Topotecanacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.