Description

Lowicryl HM23 is a specialized acrylic resin designed for low-temperature embedding in electron microscopy. This product is critical for preserving the ultrastructure and antigenicity of biological samples during the demanding dehydration and polymerization process. It is an essential material for research laboratories, diagnostic facilities, and industrial R&D departments engaged in immunocytochemistry, ultrastructural analysis, and advanced materials science.

Application

• Low-Temperature Embedding for Electron Microscopy (EM): Primary use for preparing biological specimens to minimize heat-induced damage to cellular structures.
• Immunogold Labeling Studies: Enables precise localization of antigens at the subcellular level due to excellent antigen preservation.
• Cryo-Ultrastructural Analysis: Used in protocols requiring polymerization at temperatures as low as -35°C to -50°C.
• Preparation of Thin Sections for TEM: Provides consistent, hard blocks suitable for cutting ultra-thin sections.
• Research in Cell Biology and Pathology: Facilitates high-resolution imaging of organelles, membranes, and macromolecular complexes.
• Material Science and Polymer Research: Serves as a model system for studying low-temperature curing acrylic polymers.

Basic Information

Product Name	Lowicryl HM23
CAS No.	123902-41-0
Molecular Formula	Proprietary acrylic copolymer blend
Molecular Weight	Variable (Polymer)
Synonyms	Lowicryl HM23 Embedding Resin; HM23 Acrylic Resin; Lowicryl K4M analog; Low-Temperature Embedding Medium HM23; Acrylic Embedding Resin HM23; LR White alternative (low-temp); Hydrophilic Methacrylate Resin HM23
EINECS	Contact for details

Quality Control

Every batch of Lowicryl HM23 is manufactured and tested under controlled conditions to ensure consistent performance for critical microscopy applications. We guarantee batch-to-batch reproducibility in viscosity, curing characteristics, and sectioning quality. A comprehensive Certificate of Analysis (COA) detailing lot-specific parameters is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2°C to 8°C (refrigerated) to maximize shelf life and prevent premature polymerization. Allow the resin to equilibrate to room temperature before opening the container to prevent moisture condensation. Keep away from heat and sources of free radical generation.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow viscous liquid
Identification (IR)	Conforms to standard spectrum
Viscosity (at 20°C)	Specification available upon request
Density (at 20°C)	~1.12 g/cm³
Refractive Index (Cured)	~1.48
Polymerization Temperature Range	-35°C to -50°C (under UV light)
Inhibitor Content	Contains stabilizer to prevent spontaneous polymerization
Solubility	Miscible with common dehydration solvents (e.g., ethanol, acetone)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.