Description

4-(3-(Biotinylaminohexamethylenaminocarbonyl)Propanoylaminomethyl)-2-Methyl-1,3-Dithiolane-2-Yl-(Ala(7))Phalloidin CAS NO 122856-15-9 is a highly specialized bioconjugate that combines the potent actin-binding properties of a phalloidin derivative with the high-affinity binding capability of biotin. This compound is engineered for advanced life science research, enabling precise visualization and isolation of actin filaments in complex cellular systems. It is an essential tool for researchers in cell biology, neurobiology, and pharmacology who require ultra-sensitive detection and pull-down assays.

Application

• Actin Cytoskeleton Labeling: High-resolution fluorescence or electron microscopy for studying cell morphology, motility, and division.
• Affinity Purification: Isolation and enrichment of F-actin and associated protein complexes from cell lysates using streptavidin-coated beads.
• Biochemical Assays: Quantification of actin polymerization/depolymerization dynamics in vitro.
• Drug Discovery Screening: Target-based assays to identify compounds that modulate actin filament stability.
• Neuroscience Research: Specific labeling of neuronal actin structures in synapses and growth cones.
• Diagnostic Probe Development: Potential use in developing sensitive detection systems for cellular pathologies involving cytoskeletal rearrangements.

Basic Information

Product Name	4-(3-(Biotinylaminohexamethylenaminocarbonyl)Propanoylaminomethyl)-2-Methyl-1,3-Dithiolane-2-Yl-(Ala(7))Phalloidin
CAS No.	122856-15-9
Molecular Formula	C58H91N13O12S2
Molecular Weight	~1194.6 g/mol
Synonyms	Biotin-XX Phalloidin; Biotinylated Phalloidin; Biotin-LC-Phalloidin; 6-((Biotinoyl)amino)hexanoic Acid Phalloidin Derivative; Biotinamidohexanoyl-Phalloidin; N-(6-(Biotinamido)hexanoyl)-phalloidin; Phalloidin-Biotin Conjugate; Actin Stain Biotin Conjugate
EINECS	Contact for details

Quality Control

Our 4-(3-(Biotinylaminohexamethylenaminocarbonyl)Propanoylaminomethyl)-2-Methyl-1,3-Dithiolane-2-Yl-(Ala(7))Phalloidin is produced under stringent conditions suitable for research use. Each batch undergoes rigorous analytical testing to ensure high purity, specific activity, and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and functional performance are available upon request. We adhere to quality management principles to support reliable and reproducible research outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to reach room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (Functional)	≥ 90% active conjugate
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.