Description

Dolastatin 15 is a potent, naturally-derived cytotoxic peptide originally isolated from marine sources. This compound serves as a crucial pharmacological research tool and a lead structure in the development of novel anticancer agents. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in oncology drug discovery and mechanism of action studies.

Application

• Anticancer Drug Discovery: As a key reference compound and lead structure for developing novel tubulin polymerization inhibitors and antibody-drug conjugates (ADCs).
• Biomedical Research: For studying cell cycle arrest, apoptosis induction, and the mechanisms of cytotoxicity in various cancer cell lines.
• Pharmacology Studies: Used in preclinical research to investigate pharmacokinetics, pharmacodynamics, and structure-activity relationships (SAR) of dolastatin analogs.
• Standards and Controls: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	Dolastatin 15
CAS No.	123884-00-4
Molecular Formula	C₄₅H₆₈N₆O₈
Molecular Weight	821.1 g/mol
Synonyms	Dolastatin-15; (2S)-2-[[(2S,3R)-3-Hydroxy-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylbutanoyl]amino]-3-phenylpropanoyl]amino]-N-methylbutanoyl]amino]-N,3-dimethylbutanamide; NSC 654663
EINECS	Contact for details

Quality Control

Our Dolastatin 15 is manufactured under strict quality systems suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic nature, the product should be handled in a dry environment and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.