Description

5-(n-Ethyl-(2'-Methoxy-5'-Nitrobenzyl))Amiloride is a specialized amiloride derivative, a potent and selective inhibitor of the epithelial sodium channel (ENaC). This compound is a critical research tool for studying ion transport mechanisms and related physiological pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular, renal, and pulmonary research. The product is supplied under strict quality control to ensure batch-to-batch consistency for reliable experimental results.

Application

• Biochemical Research: Used as a high-affinity, selective inhibitor of the epithelial sodium channel (ENaC) in mechanistic studies.
• Pharmacology & Drug Discovery: Serves as a reference standard and lead compound in the development of novel diuretics and treatments for hypertension, cystic fibrosis, and pulmonary edema.
• Academic Research: Fundamental tool for investigating sodium ion transport, cellular volume regulation, and electrolyte balance in cell culture and tissue models.
• Diagnostic Development: Potential use in the development of assays and kits for screening ENaC activity and related disorders.

Basic Information

Product Name	5-(n-Ethyl-(2'-Methoxy-5'-Nitrobenzyl))Amiloride
CAS No.	123844-08-6
Molecular Formula	C17H19N5O4
Molecular Weight	357.37 g/mol
Synonyms	5-(N-Ethyl-N-(2'-methoxy-5'-nitrobenzyl))amiloride; 5-(N-Ethyl-N-(2-methoxy-5-nitrobenzyl))amiloride; 5-(N-Ethyl-N-(2'-methoxy-5'-nitrobenzyl))amiloride hydrochloride; ENaC Inhibitor (5-(N-Ethyl-N-(2'-methoxy-5'-nitrobenzyl))amiloride); 5-(N-Ethyl-N-(2-methoxy-5-nitrobenzyl))amiloride HCl; Benzamil analog; Amiloride analog, nitro-substituted
EINECS	Contact for details

Quality Control

Our 5-(n-Ethyl-(2'-Methoxy-5'-Nitrobenzyl))Amiloride is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and identity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, impurities, and spectral confirmation. We ensure compliance with research-grade material standards, supporting reproducible scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.