Description

Thiorphan Disulfide is a high-purity, synthetic organic compound of significant interest in pharmaceutical research and development. This compound serves as a key intermediate and a stable disulfide-linked dimer of the potent enkephalinase inhibitor, thiorphan. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, pain management, and protease inhibitor studies. The material is supplied to meet the stringent requirements of laboratory and pre-clinical applications.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of advanced drug candidates targeting enkephalin-degrading enzymes.
• Neuroscience Research: Used as a reference standard and tool compound in studies of neuropathic pain, opioid pathways, and neurodegenerative diseases.
• Biochemical Assay Development: Employed in the development and validation of high-throughput screening assays for neutral endopeptidase (NEP) inhibition.
• Protease Inhibitor Studies: Acts as a model compound for investigating the structure-activity relationships of metalloprotease inhibitors.
• Stable Analogue Preparation: Serves as a precursor for generating more stable analogues of thiorphan for extended experimental use.

Basic Information

Product Name	Thiorphan Disulfide
CAS No.	123658-06-0
Molecular Formula	C27H36N4O6S2
Molecular Weight	576.73 g/mol
Synonyms	N-[(R,S)-3-Mercapto-2-benzylpropanoyl]glycine Disulfide; (3-Mercapto-2-benzylpropionyl)glycine Disulfide; DL-Thiorphan Disulfide; Racemic Thiorphan Disulfide; N-[2-(Benzylmethyl)-3-mercaptopropanoyl]glycine Disulfide; Enkephalinase Inhibitor Disulfide Derivative
EINECS	Contact for details

Quality Control

Our Thiorphan Disulfide is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.