Description

Ns-398 is a selective cyclooxygenase-2 (COX-2) inhibitor widely recognized for its role in biochemical and pharmacological research. This compound is crucial for studying inflammatory pathways, pain mechanisms, and the development of therapeutic agents. It is an essential tool for researchers and developers in the pharmaceutical, biotechnology, and academic sectors who require high-purity reference standards and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in the development of novel anti-inflammatory and analgesic drugs.
• Biochemical Assays: Used as a selective COX-2 inhibitor in enzymatic studies to investigate prostaglandin biosynthesis and related inflammatory cascades.
• Preclinical Studies: Employed in animal models to evaluate efficacy, pharmacokinetics, and toxicity profiles of COX-2 targeted therapies.
• Academic Research: A vital reagent for universities and research institutes studying molecular pharmacology, cell signaling, and disease mechanisms.
• API Manufacturing: Can be supplied as a high-purity building block for the synthesis of more complex pharmaceutical compounds.
• Quality Control Labs: Used as an analytical standard for method development, validation, and impurity profiling in regulatory testing.

Basic Information

Product Name	Ns-398
CAS No.	123653-11-2
Molecular Formula	C₁₃H₁₂N₂O₅S
Molecular Weight	308.31 g/mol
Synonyms	N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide; NS398; NS-398; COX-2 Inhibitor NS-398; Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-; 4-Nitro-2-phenoxymethanesulfonanilide (related); Selective COX-2 Inhibitor
EINECS	Contact for details

Quality Control

Our Ns-398 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and residual solvent analysis. Certificates of Analysis (COA) with detailed specifications are available for every batch upon request, supporting your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.