Description

Phorbol 13-Decanoate >99% is a high-purity, synthetic derivative of phorbol, a complex diterpene natural product. This compound is of significant value as a potent and specific activator of Protein Kinase C (PKC) isoforms in biochemical and pharmacological research. It is primarily needed by researchers and developers in the life sciences sector, including those working in academic institutions, pharmaceutical R&D, and biotechnology companies, for studying cell signaling pathways, tumor promotion, and inflammation mechanisms.

Application

• Biochemical Research: As a potent and selective activator of Protein Kinase C (PKC) for studying enzyme kinetics, signal transduction, and second messenger systems.
• Pharmacological Studies: Used in vitro and in vivo models to investigate the role of PKC in diseases such as cancer, diabetes, and cardiovascular disorders.
• Cell Biology: A critical tool for inducing cellular responses like proliferation, differentiation, and apoptosis in various cell lines.
• Toxicology & Cancer Research: Employed as a reference standard and tumor promoter in studies examining the mechanisms of carcinogenesis.
• Drug Discovery: Serves as a key biochemical tool for screening and validating novel PKC inhibitors or modulators in high-throughput assays.
• Neuroscience Research: Applied in studies of neurotransmitter release, synaptic plasticity, and neuronal development where PKC signaling is involved.

Basic Information

Product Name	Phorbol 13-Decanoate >99%
CAS No.	123597-59-1
Molecular Formula	C30H44O8
Molecular Weight	532.67 g/mol
Synonyms	Phorbol 13-decanoate; 12-O-Decanoylphorbol 13-acetate; 12-O-Decanoylphorbol-13-acetate; PDD; Phorbol 12,13-didecanoate (common misnomer); 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 13-decanoate 12-acetate; NSC 268551
EINECS	Contact for details

Quality Control

Our Phorbol 13-Decanoate >99% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods (NMR, MS), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	> 99.0%
Water Content (KF)	< 1.0%
Residue on Ignition	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.