Description

20-Oxo-12,20-Dideoxyphorbol 13-Isobutyrate is a high-purity, semi-synthetic diterpene ester derived from the phorbol family, known for its specific biological activity profile. This compound is a critical reference standard and advanced intermediate for pharmaceutical research, particularly in the study of protein kinase C (PKC) modulation and related signaling pathways. It is essential for researchers and developers in the fields of oncology, immunology, and dermatology who require well-characterized, high-quality biochemical tools for drug discovery and mechanism-of-action studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in drug substance and product testing.
• Biochemical Research: Used as a potent and specific tool compound in cell-based and enzymatic assays to investigate PKC-mediated signal transduction mechanisms.
• Drug Discovery & Development: Acts as a key intermediate or pharmacophore model in the synthesis of novel therapeutic agents targeting cancer and inflammatory diseases.
• Academic Research: Employed in university and institutional labs for fundamental studies in cell biology, toxicology, and molecular pharmacology.
• Contract Research Organization (CRO) Support: Supplied to CROs for client-sponsored preclinical research and safety assessment studies.

Basic Information

Product Name	20-Oxo-12,20-Dideoxyphorbol 13-Isobutyrate
CAS No.	123597-58-0
Molecular Formula	C28H38O7
Molecular Weight	486.60 g/mol
Synonyms	12-Deoxyphorbol 13-isobutyrate 20-acetate; 20-Oxo-12-deoxyphorbol 13-isobutyrate; 12,20-Dideoxy-20-oxophorbol 13-isobutyrate; NSC 328426; Prostratin analog; DPP 13-isobutyrate; 13-O-Isobutyryl-12-deoxyphorbol-20-al; 20-Oxo-12-deoxyphorbol-13-isobutyrate
EINECS	Contact for details

Quality Control

Every batch of 20-Oxo-12,20-Dideoxyphorbol 13-Isobutyrate is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our products are suitable for use as reference materials in regulated environments. A comprehensive Certificate of Analysis (COA) detailing purity by HPLC, identity confirmation (NMR, MS), and impurity profiles is provided with each shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.