Description

Tyrosyl-Alanyl-Lysyl-Arginine Chloromethyl Ketone is a synthetic, sequence-specific peptide chloromethyl ketone designed as a potent and irreversible inhibitor of serine proteases. This compound is critical for biochemical research and pharmaceutical development, offering precise control over enzymatic activity studies. It is primarily utilized by researchers and manufacturers in the fields of protease inhibitor development, drug discovery, and diagnostic assay formulation.

Application

• Biochemical Research: As a specific, irreversible inhibitor for studying serine protease mechanisms and kinetics.
• Pharmaceutical Development: Used in the design and screening of novel therapeutic agents targeting specific proteolytic pathways.
• Diagnostic Reagents: A key component in the development of enzyme-linked assays and diagnostic kits for clinical research.
• Cell Biology Studies: Employed to inhibit specific proteases in cell culture and tissue models to elucidate their biological functions.
• Proteomics: A tool for the selective inhibition of target proteases in complex protein mixtures for analytical purposes.

Basic Information

Product Name	Tyrosyl-Alanyl-Lysyl-Arginine Chloromethyl Ketone
CAS No.	123496-54-8
Molecular Formula	C30H50ClN9O7
Molecular Weight	684.2 g/mol
Synonyms	Y-A-K-R-CMK; TFAK-CMK; Tyr-Ala-Lys-Arg-CH2Cl; Chloromethyl Ketone Inhibitor YAKR; Peptidyl Chloromethyl Ketone; Serine Protease Inhibitor YAKR; Ac-Tyr-Ala-Lys-Arg-CH2Cl; N-Acetyl-Tyr-Ala-Lys-Arg-chloromethylketone
EINECS	Contact for details

Quality Control

Our Tyrosyl-Alanyl-Lysyl-Arginine Chloromethyl Ketone is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation by mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.