Description

n-(2-Fluoropyridine-4-Carbonyl)-L-Proline is a high-purity, fluorinated proline derivative designed for advanced pharmaceutical research and development. This compound serves as a critical chiral building block and intermediate in the synthesis of complex bioactive molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel drug candidates, particularly in areas targeting proteases and other enzymes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorinated motifs and conformational constraints.
• Peptidomimetic Design: Incorporated into peptide analogs to enhance metabolic stability, bioavailability, and binding affinity.
• Chemical Biology Probe: Serves as a tool compound for studying enzyme mechanisms and protein-ligand interactions.
• Process Chemistry: Employed in the scale-up and route development for the commercial manufacturing of fluorinated drug substances.
• Custom Synthesis: A starting material for the tailored synthesis of more complex fluorinated heterocycles and specialized fine chemicals.

Basic Information

Item	Details
Product Name	n-(2-Fluoropyridine-4-Carbonyl)-L-Proline
CAS No.	123412-43-1
Molecular Formula	C11H9FN2O3
Molecular Weight	236.20 g/mol
Synonyms	L-Proline, 1-[(2-fluoro-4-pyridinyl)carbonyl]-; 1-[(2-Fluoropyridin-4-yl)carbonyl]-L-proline; (S)-1-(2-Fluoropyridine-4-carbonyl)pyrrolidine-2-carboxylic acid; 2-Fluoropyridine-4-carboxylic acid L-proline amide; n-(2-Fluoro-4-pyridinecarbonyl)-L-proline; (2S)-1-(2-Fluoropyridine-4-carbonyl)pyrrolidine-2-carboxylic acid; Fluoropyridine-proline conjugate
EINECS	Contact for details

Quality Control

Our n-(2-Fluoropyridine-4-Carbonyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.