Description

18-Nor-3-Ketoaphidicolin is a structurally modified diterpenoid derivative of the natural product aphidicolin, a well-known inhibitor of DNA polymerase. This compound is of significant interest in biochemical and pharmacological research due to its potential as a more potent or selective tool for studying eukaryotic DNA replication and cell cycle progression. It serves as a critical reference standard and intermediate for researchers in pharmaceutical development, oncology research, and molecular biology, enabling the exploration of novel therapeutic agents targeting DNA synthesis.

Application

• Biochemical Research: Used as a potent and selective inhibitor in studies of eukaryotic DNA polymerases (α, δ, and ε) to elucidate DNA replication mechanisms.
• Pharmaceutical R&D: Serves as a key intermediate or reference standard in the synthesis and development of novel anti-cancer and antiviral agents.
• Cell Biology Studies: Employed to induce cell cycle arrest, specifically at the G1/S phase boundary, for investigating cell proliferation and checkpoint controls.
• Oncology Research: Utilized as a tool compound to study tumor cell growth inhibition and to screen for compounds with enhanced therapeutic indices.
• Enzyme Kinetics: Acts as a specific substrate analog in enzymatic assays to determine inhibition constants and mechanistic pathways.
• Chemical Synthesis: Functions as a sophisticated building block for the semi-synthesis of complex diterpenoid libraries for structure-activity relationship (SAR) studies.

Basic Information

Product Name	18-Nor-3-Ketoaphidicolin
CAS No.	123355-76-0
Molecular Formula	C19H28O4
Molecular Weight	320.43 g/mol
Synonyms	18-Noraphidicolin-3-one; 3-Keto-18-noraphidicolin; 18-Noraphidicolan-3-one; NSC 339586; Aphidicolin-18-nor-3-one derivative; DNA Polymerase Inhibitor 18-nor analog; (3S,4aR,6aS,9aS,9bR,10S,10aS)-10-Hydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1,3,4,4a,5,6,6a,9,9a,9b,10,10a-dodecahydro-2H-benzo[f]chromen-8-yl acetate
EINECS	Contact for details

Quality Control

Our 18-Nor-3-Ketoaphidicolin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.