Description

Aphidicolin Glycinate is a chemically modified derivative of the natural tetracyclic diterpenoid, aphidicolin, designed for enhanced stability and solubility in biological research applications. This compound is a potent and selective inhibitor of eukaryotic DNA polymerase α and δ, making it a critical tool for cell cycle synchronization and studying DNA replication mechanisms. It is primarily utilized by researchers in pharmaceutical R&D, academic biochemistry, and biotechnology sectors focused on oncology, virology, and cell biology.

Application

• Cell Cycle Research: Used to reversibly arrest cells at the G1/S phase boundary for synchronization studies.
• DNA Replication Studies: Acts as a specific inhibitor of nuclear DNA polymerases to investigate replication dynamics and checkpoint controls.
• Antiviral Research: Employed in studies targeting viral DNA replication, particularly for herpesviruses and poxviruses.
• Oncology and Cancer Biology: Utilized to probe the mechanisms of cell proliferation and to evaluate potential chemotherapeutic agents.
• Biochemical Assay Development: Serves as a reference standard in enzymatic assays for polymerase activity screening.
• Stem Cell Research: Applied in protocols to control the proliferation of stem cells for differentiation studies.

Basic Information

Product Name	Aphidicolin Glycinate
CAS No.	123252-56-2
Molecular Formula	C₂₇H₄₁NO₈
Molecular Weight	507.62 g/mol
Synonyms	Aphidicolin Glycinate; Aphidicolin 17-Glycinate; ((3aR,4S,5S,7R,7aR,10aS,11R,11aS)-4,7,10a,11-Tetramethyl-1,2,3,3a,5,6,7,7a,8,9,10,11a-dodecahydro-4,7-methano-11H-cyclopenta[a]cyclopropa[f][11]annulen-11-yl) 2-aminoacetate; Aphidicolin Glycine Ester; DNA Polymerase Inhibitor Aphidicolin Glycinate
EINECS	Contact for details

Quality Control

Our Aphidicolin Glycinate is manufactured under strict quality systems suitable for research use. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and determination of residual solvents and moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.