Description

25-Dehydro-1,25-Dihydroxy-26-Methylvitamin D3 is a synthetic analog of the biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol). This compound is of significant interest for its potential to modulate calcium metabolism and cell differentiation with a distinct pharmacological profile. It is primarily utilized in advanced pharmaceutical research and development, particularly for studying vitamin D receptor (VDR) signaling pathways and developing novel therapeutics for conditions like osteoporosis, psoriasis, and certain cancers.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel vitamin D analogs.
• Biochemical Studies: For investigating the structure-activity relationships (SAR) of vitamin D derivatives and their interaction with the Vitamin D Receptor (VDR).
• Metabolic Disorder Research: Used in preclinical studies targeting diseases related to calcium and phosphate homeostasis, such as chronic kidney disease-mineral and bone disorder (CKD-MBD).
• Oncology Research: Exploration of anti-proliferative and pro-differentiating effects on various cancer cell lines.
• Dermatology Research: Investigation into potential treatments for hyperproliferative skin disorders like psoriasis.
• Academic & Institutional Research: Serves as a critical reagent in universities and research institutes for endocrinology and molecular biology studies.

Basic Information

Product Name	25-Dehydro-1,25-Dihydroxy-26-Methylvitamin D3
CAS No.	123000-44-2
Molecular Formula	C₂₈H₄₂O₃
Molecular Weight	426.64 g/mol
Synonyms	26-Methyl-1,25-dihydroxyvitamin D3; 26-Methyl-calcitriol; 1α,25-Dihydroxy-26-methylvitamin D3; 25-Dehydro-1α,25-dihydroxy-26-methylcholecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1α,3β,26-triol, 26-methyl-; 26-Methyl-1α,25-dihydroxycholecalciferol; 26-Methyl-1,25-(OH)₂D₃
EINECS	Contact for details

Quality Control

Our 25-Dehydro-1,25-Dihydroxy-26-Methylvitamin D3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets high-purity research standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.