Description

(+)-Xestospongin B CAS NO 123000-02-2 is a high-purity, naturally-derived marine alkaloid known for its potent and selective antagonism of inositol 1,4,5-trisphosphate (IP3) receptor-mediated calcium signaling. This specific activity makes it a critical research tool for studying intracellular calcium dynamics, a fundamental process in cell biology, neurobiology, and pharmacology. It is primarily utilized by researchers and scientists in pharmaceutical R&D, academic institutions, and biotechnology companies focused on neurological disorders, cardiovascular research, and cellular signaling pathways.

Application

• Biochemical Research: A selective and potent inhibitor of IP3 receptor-mediated Ca2+ release, used to elucidate calcium signaling mechanisms in various cell types.
• Neuroscience Studies: Investigates the role of intracellular calcium in neuronal function, synaptic plasticity, and models of neurodegenerative diseases.
• Cardiovascular Research: Explores calcium-induced calcium release (CICR) in cardiac myocytes and smooth muscle cells.
• Pharmacological Screening: Serves as a reference compound and tool in high-throughput screening for novel IP3 receptor modulators.
• Cell Biology: Used to study apoptosis, cell proliferation, and other cellular processes regulated by IP3-mediated calcium fluxes.
• Academic & Institutional Research: Essential reagent for graduate and post-doctoral research projects in molecular and cellular biology.

Basic Information

Product Name	(+)-Xestospongin B
CAS No.	123000-02-2
Molecular Formula	C22H23NO4
Molecular Weight	365.42 g/mol
Synonyms	Xestospongin B; (+)-Xestospongin B; Xestospongin B, (1S,2R,5S,6R,10S,13R,14R)-form; (1S,2R,5S,6R,10S,13R,14R)-2,14-Dimethyl-1,6,13-trihydroxy-9,15-dioxapentacyclo[10.5.1.01,10.02,6.05,14]octadec-11-ene-8,16-dione; IP3 Receptor Antagonist Xestospongin B
EINECS	Contact for details

Quality Control

Our (+)-Xestospongin B is produced under stringent quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) containing purity data, chromatograms, and storage recommendations is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.