Description

Esperamicin A1 Aglycone is a potent enediyne antibiotic core structure, representing a critical intermediate in the study and development of novel antitumor agents. Its significance lies in its role as the pharmacophore responsible for the DNA-cleaving activity of the esperamicin family, making it a valuable reference standard and research tool. This compound is essential for pharmaceutical R&D laboratories, academic institutions, and biotechnology companies focused on oncology drug discovery, mechanism-of-action studies, and the synthesis of new bioactive derivatives.

Application

• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and identification in the development of enediyne-based anticancer drugs.
• Biochemical Research: Serves as a key tool for studying DNA damage mechanisms, apoptosis induction, and the biological activity of enediyne warheads.
• Medicinal Chemistry Intermediate: Acts as a core scaffold for the semi-synthesis and structural modification of novel antitumor compounds with potentially improved efficacy or reduced toxicity.
• Academic Research: Utilized in university and institutional labs for fundamental research into antibiotic biosynthesis, mode of action, and structure-activity relationships (SAR).
• Antitumor Agent Development: Investigated for its potential in the design of antibody-drug conjugates (ADCs) and other targeted cancer therapies.

Basic Information

Product Name	Esperamicin A1 Aglycone
CAS No.	122951-93-3
Molecular Formula	C28H30N2O8S
Molecular Weight	554.61 g/mol
Synonyms	Esperamicin A1 Aglycon; Esperamicinone A1; (1S,5R,8S,17R)-8-[(2R,3S,4S,6R)-3,4-Dihydroxy-6-methyl-5-oxanyl]-17-ethyl-5-hydroxy-11,15-dimethyl-4,7,10,14-tetraoxo-3-oxa-6,11,15-triazatetracyclo[11.3.1.1²,⁶.0⁵,¹⁷]octadeca-2(18),12,14,16-tetraene-9,13-dithial; Enediyne core of Esperamicin A1; DNA-cleaving aglycone of Esperamicin A1
EINECS	Contact for details

Quality Control

Our Esperamicin A1 Aglycone is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for reference materials, ensuring reliability for your critical pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below to minimize oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content	≤ 1.0%
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.