Description

Itopride is a selective benzamide derivative and a potent prokinetic agent that acts as a dual antagonist of dopamine D2 receptors and an acetylcholinesterase inhibitor. This mechanism is critical for enhancing gastrointestinal motility and coordination, making it a valuable active pharmaceutical ingredient (API). It is primarily utilized in the formulation of prescription medications for the treatment of functional dyspepsia and other upper gastrointestinal motility disorders. Global pharmaceutical manufacturers and research organizations rely on high-purity Itopride CAS NO 122898-67-3 for developing safe and effective therapeutic solutions.

Application

• Pharmaceutical API: Primary use as the active ingredient in tablets and capsules for treating functional dyspepsia, gastroparesis, and chronic gastritis.
• Gastrointestinal Prokinetic Drugs: Formulation of medications that enhance gastric emptying and improve symptoms like bloating, early satiety, and upper abdominal pain.
• Clinical Research: Serves as a reference standard and raw material in pharmacokinetic, pharmacodynamic, and new drug delivery system (NDDS) studies.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing digestive disorders in animals.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded prokinetic drugs.
• Biochemical Research: Used as a tool compound in pharmacological studies targeting dopaminergic and cholinergic systems in the gut.

Basic Information

Item	Detail
Product Name	Itopride
CAS No.	122898-67-3
Molecular Formula	C20H26N2O4
Molecular Weight	358.43 g/mol
Synonyms	Itopride Hydrochloride; N-[4-[2-(Dimethylamino)ethoxy]benzyl]-3,4-dimethoxybenzamide; Itopridum; Ganaton (Brand Name); KW-5338; Itopride HCl; 3,4-Dimethoxy-N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]benzamide
EINECS	Contact for details

Quality Control

Our Itopride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. We provide supporting Certificates of Analysis (COA) that detail results from tests such as HPLC assay, related substances, residual solvents, and heavy metals. Our quality commitment aligns with cGMP principles and relevant pharmacopoeial standards to guarantee consistency and reliability for our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.