Description

Alosetron Hydrochloride is a highly selective serotonin 5-HT3 receptor antagonist, a critical active pharmaceutical ingredient (API) with significant therapeutic value. Its primary commercial importance lies in the targeted treatment of severe irritable bowel syndrome with diarrhea (IBS-D) in specific patient populations, where it modulates visceral pain and gastrointestinal transit. This compound is essential for pharmaceutical manufacturers and research organizations engaged in developing and producing specialized neurological and gastroenterological medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for severe, chronic IBS-D.
• Neurological Research: Used in studies investigating the role of 5-HT3 receptors in pain perception, anxiety, and emesis (vomiting).
• Gastroenterological Research: Applied in preclinical and clinical research for understanding and treating functional gastrointestinal disorders.
• Reference Standard: Serves as a high-purity chemical reference standard for quality control and analytical method development in regulatory and laboratory settings.
• Formulation Development: Utilized in the R&D of novel drug delivery systems, such as controlled-release tablets or capsules.

Basic Information

Product Name	Alosetron Hydrochloride
CAS No.	122852-69-1
Molecular Formula	C17H18N4O·HCl
Molecular Weight	330.81 g/mol
Synonyms	Alosetron HCl; GR 68755C; 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride; Lotronex (Brand Name); 5-Methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one Hydrochloride
EINECS	Contact for details

Quality Control

Our Alosetron Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing to ensure it meets stringent pharmaceutical-grade specifications, including identity, purity, and impurity profile. We provide full traceability and support regulatory submissions. A detailed Certificate of Analysis (COA) is available for every lot, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.