Description

Protein Kinase Inhibitor (6-22)Amide, 4-Azidophenylalanine(10)- CAS NO 122756-41-6 is a synthetic peptide-based inhibitor designed for targeted biochemical research. This compound is a critical tool for studying signal transduction pathways, specifically those mediated by protein kinases, due to its precise inhibitory action. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in drug discovery and molecular biology. Its design incorporates a photoactivatable azido group, enabling advanced cross-linking studies for target identification and validation.

Application

• Biochemical Research: Fundamental studies on protein kinase activity, enzyme kinetics, and signal transduction mechanisms.
• Drug Discovery & Development: High-throughput screening (HTS) campaigns and lead compound validation in oncology and metabolic disease research.
• Target Identification: Photoaffinity labeling using the 4-azidophenylalanine moiety to covalently bind and isolate kinase targets in complex biological samples.
• Cellular Pathway Analysis: Investigation of specific kinase roles in cell proliferation, differentiation, and apoptosis.
• Proteomics: Used as a molecular probe in activity-based protein profiling (ABPP) to map kinome-wide interactions.
• Reagent Manufacturing: Serves as a key intermediate or reference standard for producing specialized assay kits and research tools.

Basic Information

Product Name	Protein Kinase Inhibitor (6-22)Amide, 4-Azidophenylalanine(10)- CAS NO 122756-41-6
CAS No.	122756-41-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PKI(6-22) amide, 4-Azido-Phe(10)-PKI(6-22) amide; Protein Kinase Inhibitor Peptide (6-22), 4-Azido-L-phenylalanine(10); PKI Peptide; cAMP-dependent Protein Kinase Inhibitor (6-22) amide, AzF(10) analog; Photoactivatable PKI; AHA-PKI(6-22); Research Compound 122756-41-6
EINECS	Contact for details

Quality Control

Our Protein Kinase Inhibitor (6-22)Amide, 4-Azidophenylalanine(10) is produced under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.