Description

Mycalolide B is a potent marine-derived macrolide compound with significant biological activity. This high-purity biochemical is valued for its unique mechanism of action as a selective actin-depolymerizing agent, making it a critical tool for cytoskeleton research and targeted therapeutic development. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in cell biology, oncology, and pharmacology studies.

Application

• Biochemical Research: A key tool compound for studying actin filament dynamics, cell motility, and cytoskeletal architecture in vitro.
• Pharmaceutical Discovery: Used in target validation and screening assays for developing novel anti-cancer and anti-metastatic therapeutics.
• Cell Biology Studies: Employed to investigate processes such as cytokinesis, cell adhesion, and morphological changes by selectively disrupting the actin network.
• Mechanism of Action (MoA) Studies: Serves as a precise molecular probe to elucidate biological pathways dependent on actin polymerization.
• High-Content Screening (HCS): Utilized in phenotypic screening platforms to identify compounds that modulate the cytoskeleton.

Basic Information

Product Name	Mycalolide B
CAS No.	122752-21-0
Molecular Formula	C₄₇H₇₀N₄O₁₂
Molecular Weight	883.1 g/mol
Synonyms	Mycalolide-B; Mycalolide B (from Mycale sp.); 34-Deacetylmycalolide B; (3S,4S,5S,7R,8S,9S,11S,12R,13S,14S,16R,18S,20S,22R,24S,26S,28S,30S,32S,34S,36S,38S,40S,42S,44S,46S)-44-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-46-hydroxy-5,7,9,11,13,22,24,26,28,30,32,34,36,38,40,42-hexadecahydroxy-4,8,12,16,20-pentamethyl-3,47-dioxo-47-[(1E,3E,5E,7E)-1,3,5,7,9,11,13,15,17-nonadecanonaen-1-yl]-2,6,10,14,18-pentaoxa-1(2,6)-oxazolina-47-azatricyclo[40.4.0.0¹⁹,²³]hexatetracontane-30-carboxylic acid
EINECS	Contact for details

Quality Control

Our Mycalolide B is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95%
Assay	≥90% (by HPLC)
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.