Description

Tulopafant CAS NO 122570-29-0 is a potent and selective platelet-activating factor (PAF) receptor antagonist. This compound is a critical research tool for investigating the role of PAF in inflammatory pathways, thrombosis, and related physiological processes. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutic agents for inflammatory and cardiovascular diseases.

Application

• Pharmacological Research: A key reference standard and active compound for studying PAF-mediated signaling and receptor antagonism in vitro and in vivo.
• Drug Discovery & Development: Used as a lead compound or benchmark in the development of new anti-inflammatory and anti-thrombotic agents.
• Biochemical Assays: Employed to validate and calibrate assays targeting the PAF receptor for high-throughput screening and mechanistic studies.
• Academic Research: Supports fundamental research in immunology, vascular biology, and anaphylaxis to elucidate disease mechanisms.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical analysis.

Basic Information

Product Name	Tulopafant
CAS No.	122570-29-0
Molecular Formula	C27H29N3O4
Molecular Weight	459.54 g/mol
Synonyms	Y-24180; Tulopafant (Y-24180); 4-(2-Chlorophenyl)-2-[2-(4-isobutylphenyl)ethyl]-1,2,4-triazolidine-3,5-dione; 1,2,4-Triazolidine-3,5-dione, 4-(2-chlorophenyl)-2-[2-[4-(2-methylpropyl)phenyl]ethyl]-; Y 24180; Y24180
EINECS	Contact for details

Quality Control

Our Tulopafant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed results to ensure compliance with research-grade standards. Specifications can be tailored to meet specific project requirements, including GMP-grade synthesis for advanced development phases.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C. Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.