Description

Soraphen A CAS NO 122547-72-2 is a potent, naturally occurring macrocyclic polyketide compound that functions as a highly specific inhibitor of acetyl-CoA carboxylase (ACC). This compound matters significantly for researchers as a critical pharmacological tool for studying lipid metabolism, cellular signaling, and metabolic disorders. It is primarily needed by biotechnology and pharmaceutical R&D teams for target validation, mechanism-of-action studies, and as a lead compound in metabolic disease drug discovery programs.

Application

• Biochemical Research: Used as a selective inhibitor of acetyl-CoA carboxylase (ACC1 and ACC2) to investigate fatty acid synthesis and oxidation pathways in cellular and animal models.
• Metabolic Disease Studies: A key tool compound for research into obesity, type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and other disorders linked to dysregulated lipid metabolism.
• Antifungal Mechanism Research: Explored for its original natural role as a fungicide, providing insights into novel modes of action against plant and human fungal pathogens.
• Oncology Research: Investigated for its potential to inhibit cancer cell proliferation by disrupting the lipogenic pathway essential for tumor growth.
• Veterinary & Agricultural Research: Serves as a reference standard and active ingredient in studies for developing new antifungal or metabolic regulating agents.
• High-Throughput Screening (HTS): Utilized as a control or reference compound in assay development and screening campaigns targeting ACC or related metabolic enzymes.

Basic Information

Product Name	Soraphen A
CAS No.	122547-72-2
Molecular Formula	C₂₇H₄₀O₈
Molecular Weight	492.60 g/mol
Synonyms	Soraphen A; Soraphen A1α; Soraphen; (3S,4R,5S,6R,8R,10R,11R,12S,13E,15E,17E,19E,21S,23R,25S,26R)-23-Ethyl-4,5,10,11,21,25-hexahydroxy-3,6,8,12,26-pentamethyl-9-oxo-1-oxacyclohexacosa-13,15,17,19-tetraene-2,7-dione; ACC Inhibitor Soraphen A; Acetyl-CoA Carboxylase Inhibitor
EINECS	Contact for details

Quality Control

Our Soraphen A is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing including HPLC purity analysis, NMR and MS confirmation of structure, and determination of residual solvents and moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. For long-term storage under inert atmosphere, the product should be kept sealed under argon or nitrogen. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular mass
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, Ethanol, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.