Description

Tyrphostin A51 CAS NO 122520-90-5 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. This compound is a critical research tool for elucidating signal transduction pathways and studying cellular processes related to growth, proliferation, and differentiation. It is primarily utilized by researchers and scientists in the fields of oncology, biochemistry, and molecular biology for in vitro and in vivo studies.

Application

• Biochemical Research: A key reagent for studying EGFR-mediated signal transduction pathways and their role in cell function.
• Oncology Research: Used to investigate the mechanisms of cancer cell proliferation and to evaluate potential therapeutic targets.
• Enzyme Inhibition Studies: Serves as a specific inhibitor in assays to determine the activity and role of EGFR tyrosine kinase.
• Cell Biology: Employed to modulate cellular responses to growth factors and to study effects on differentiation and apoptosis.
• Pharmaceutical Development: Acts as a reference compound or lead structure in the discovery and development of novel kinase inhibitors.
• Academic Research: Widely used in university and institutional labs for fundamental research in life sciences.

Basic Information

Product Name	Tyrphostin A51
CAS No.	122520-90-5
Molecular Formula	C15H12N2O3
Molecular Weight	268.27 g/mol
Synonyms	AG 151; AG-151; AG151; Tyrphostin AG 151; 3,4-Dihydroxy-α-cyanocinnamomitrile; α-Cyano-3,4-dihydroxycinnamamide; EGFR Tyrosine Kinase Inhibitor AG151; RG 50810; RG-50810; RG50810
EINECS	Contact for details

Quality Control

Tyrphostin A51 is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by the global research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain integrity.

Specification

Item	Specification
Appearance	Yellow to brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.