Description

Tyrphostin 11 CAS NO 122520-73-4 is a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, belonging to the tyrphostin class of compounds. This small molecule inhibitor is a critical research tool for elucidating signal transduction pathways and developing targeted therapeutic strategies. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for biochemical and pharmacological studies.

Application

• Biomedical Research: A key reagent for studying EGFR-mediated signaling cascades in cancer cell biology, proliferation, and apoptosis.
• Drug Discovery & Development: Serves as a reference compound and a lead structure in the design of novel tyrosine kinase inhibitors for oncology.
• Enzyme Inhibition Studies: Used in in vitro assays to characterize the kinetics and specificity of EGFR tyrosine kinase activity.
• Cellular Pathway Analysis: Employed to dissect the role of EGFR in various cellular processes, including differentiation and migration.
• Academic & Institutional Research: Fundamental tool for graduate and post-doctoral research in molecular biology and pharmacology departments.
• Preclinical Model Validation: Used in animal and cell-based models to validate targets and understand mechanisms of action for potential therapeutics.

Basic Information

Product Name	Tyrphostin 11
CAS No.	122520-73-4
Molecular Formula	C16H12N2O3
Molecular Weight	280.28 g/mol
Synonyms	AG 555; Tyrphostin AG 555; RG 50810; 2-[(3-Bromophenyl)amino]benzo[h]chromene-3-carbonitrile; Benzo[h]chromene-3-carbonitrile, 2-[(3-bromophenyl)amino]-; EGFR Tyrosine Kinase Inhibitor AG555
EINECS	Contact for details

Quality Control

Our Tyrphostin 11 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.