Description

Methyl 5-Fluoro-2-Methoxynicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex molecules with tailored biological and material properties. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorine and methoxy-substituted nicotinate motifs.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluoronicotinate scaffold enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or fluorinated polymers for specific optical properties.
• Chemical Biology Probes: Utilized to build fluorescent tags or molecular probes for studying enzyme mechanisms and cellular processes.
• Custom Synthesis and Scale-up: A fundamental substrate for contract research and manufacturing organizations (CROs/CMOs) performing custom synthesis for client projects.

Basic Information

Product Name	Methyl 5-Fluoro-2-Methoxynicotinate
CAS No.	122433-52-7
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	5-Fluoro-2-methoxynicotinic acid methyl ester; Methyl 5-fluoro-2-methoxypyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-fluoro-2-methoxy-, methyl ester; 2-Methoxy-5-fluoronicotinic acid methyl ester; 5-Fluoro-2-methoxy-3-pyridinecarboxylic acid methyl ester; Methyl 5-fluoro-2-methoxy-3-pyridinecarboxylate; 122433-52-7
EINECS	Contact for details

Quality Control

Our Methyl 5-Fluoro-2-Methoxynicotinate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. For projects requiring specific regulatory support, we can discuss documentation aligned with cGMP or ISO standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Area %)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.