Description

Etoposide Phosphate Disodium CAS NO 122405-33-8 is a highly soluble, water-soluble prodrug of the potent topoisomerase II inhibitor, etoposide. This enhanced solubility profile is critical for formulating stable, injectable pharmaceutical solutions, overcoming a key limitation of the parent compound. It is an essential active pharmaceutical ingredient (API) and key intermediate for manufacturers in the oncology sector, primarily used in the development and production of chemotherapeutic agents targeting various cancers, including testicular and small cell lung cancer.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable anti-cancer formulations.
• Oncology Drug Manufacturing: Critical intermediate in the synthesis of finished dosage forms like lyophilized powders or sterile solutions for infusion.
• Research & Development: Used in biochemical and pharmacological studies to investigate topoisomerase II inhibition and cancer cell apoptosis mechanisms.
• Preclinical Studies: Employed in animal models for efficacy and pharmacokinetic profiling of novel etoposide-based therapies.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Combination Therapies: A component in developing combination chemotherapeutic regimens to enhance treatment efficacy.

Basic Information

Product Name	Etoposide Phosphate Disodium
CAS No.	122405-33-8
Molecular Formula	C29H31O16PNa2
Molecular Weight	728.48 g/mol
Synonyms	Etoposide 4'-Phosphate Disodium Salt; Etoposide Phosphate Sodium Salt; NSC 752008; BMY-40481-30; 4'-Demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside], 4'-(dihydrogen phosphate) disodium salt; VP-16 Phosphate Disodium; (5S,5aR,8aR,9R)-5-[[4,6-O-[(1R)-Ethylidene]-β-D-glucopyranosyl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydro-5aH-isobenzofuro[5,6-f][1,3]benzodioxol-6(6aH)-one 4'-(Dihydrogen Phosphate) Disodium Salt
EINECS	Contact for details

Quality Control

Our Etoposide Phosphate Disodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and stringent control of residual solvents and impurities to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.