Description

Temoporfin is a second-generation, synthetic photosensitizer belonging to the porphyrin family, widely recognized for its application in photodynamic therapy (PDT). Its primary value lies in its high selectivity and efficacy in generating cytotoxic singlet oxygen upon activation with light of a specific wavelength, enabling targeted therapeutic action. This makes it a critical active pharmaceutical ingredient (API) for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly those developing advanced oncology treatments and dermatological therapies.

Application

• Photodynamic Therapy (PDT) for Oncology: As a key active pharmaceutical ingredient (API) in formulations for treating certain types of cancer, including head and neck cancers, where it is activated by laser light to destroy malignant cells.
• Dermatological Treatments: Used in the development of topical or systemic treatments for actinic keratosis, basal cell carcinoma, and other skin conditions amenable to PDT.
• Antimicrobial Photodynamic Therapy (aPDT): Investigated for its potential to inactivate bacteria, viruses, and fungi, supporting R&D in novel anti-infective strategies.
• Pharmaceutical Research & Development: Serves as a reference standard and a critical raw material for drug discovery, formulation studies, and pharmacokinetic research in academic and industrial labs.
• Pre-clinical and Clinical Studies: Supplied to contract research organizations (CROs) and biopharma companies conducting efficacy and safety trials for new PDT-based drugs.
• Advanced Drug Delivery Systems: Incorporated into research on liposomal, nanoparticle, or other targeted delivery platforms to enhance the specificity and reduce side effects of PDT.

Basic Information

Product Name	Temoporfin
CAS No.	122341-38-2
Molecular Formula	C44H32N4O4
Molecular Weight	680.75 g/mol
Synonyms	m-THPC; Foscan; Temoporfin; 5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin; meta-Tetrahydroxyphenylchlorin; 3,3',3'',3'''-(21H,23H-Porphine-5,10,15,20-tetrayl)tetrakis-phenol
EINECS	Contact for details

Quality Control

Our Temoporfin is manufactured under strict quality management systems to ensure it meets the exacting standards required for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and spectroscopy. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability, consistency, and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its strictly light-sensitive nature, all handling and storage must be performed under conditions that protect the material from all light exposure to maintain stability and potency.

Specification

Item	Specification
Appearance	Dark green to brownish-green solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.