Description

Mivobulin is a synthetic microtubule-destabilizing agent and potent antimitotic compound used primarily in pharmaceutical research and oncology drug development. It offers high target specificity and reproducible cytostatic activity, making it a critical reference standard for mechanistic studies and assay validation. Researchers in academic laboratories, biopharmaceutical CROs, and API development teams rely on rigorously characterized Mivobulin CAS NO 122332-18-7 for preclinical target engagement profiling and structure–activity relationship (SAR) analysis.

Application

• Oncology drug discovery: As a biochemical tool for studying microtubule dynamics and mitotic arrest mechanisms
• Reference standard in HPLC and LC-MS/MS quantitative assays for antimitotic compound analysis
• Lead optimization support in medicinal chemistry programs targeting tubulin-binding agents
• In vitro cytotoxicity screening across human cancer cell lines (e.g., HeLa, A549, MCF-7)
• Quality control benchmark for generic or biosimilar tubulin inhibitor formulations
• Calibration material in regulatory bioanalytical method validation (ICH M10 compliant)
• Stability-indicating assay development for light- and oxidation-sensitive APIs

Basic Information

Product Name	Mivobulin
CAS No.	122332-18-7
Molecular Formula	C28H30N2O5
Molecular Weight	474.55 g/mol
Synonyms	Mivobulin; NSC 670051; (3R,4S)-N-(3,4-Dimethoxyphenyl)-4-hydroxy-3-methoxy-5-(3-methyl-2-butenyl)benzamide; Mivobulin hydrate; Mivobulin free base; 3',4'-Dimethoxy-3-hydroxy-4-methoxy-5-(3-methyl-2-butenyl)benzanilide; Mivo; NSC-670051; CID 11597540
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Mivobulin are tested per ICH Q2(R2) guidelines for identity, assay, related substances, residual solvents, and heavy metals. Testing includes HPLC purity determination (≥99.0%), IR spectroscopic confirmation, and chiral purity assessment where applicable. Materials conform to ISO 9001-certified manufacturing practices and are fully REACH-compliant.

Storage

Preserve in a tightly closed container, protected from light. Store under inert atmosphere (nitrogen or argon) at 2–8 °C. Keep away from oxidizing agents and sources of heat or ignition. Maintain low humidity conditions (<40% RH) to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	99.0–101.0%
Related Substances (HPLC)	≤0.5% total impurities
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤10 ppm
Water Content (KF)	≤0.5%
Optical Rotation ([α]D²⁵)	–15.0° to –18.0° (c = 1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.