Description

N,n-Dimethylsphingosine is a synthetic, cell-permeable derivative of sphingosine, a key bioactive lipid mediator. This compound serves as a potent and selective inhibitor of sphingosine kinase (SphK), a critical enzyme in the sphingolipid metabolic pathway. It is an essential research tool for scientists in the fields of cell biology, immunology, and oncology, enabling the study of cellular signaling, apoptosis, and inflammation. The product is supplied under the identifier CAS NO 122314-67-4.

Application

• Biochemical Research: A critical tool for studying the sphingolipid rheostat, specifically the role of sphingosine-1-phosphate (S1P) vs. ceramide/sphingosine in cell signaling pathways.
• Oncology Research: Used to investigate the inhibition of sphingosine kinase and its impact on cancer cell proliferation, survival, and resistance to chemotherapy.
• Immunology & Inflammation Studies: Applied to modulate S1P-dependent processes in immune cell trafficking, cytokine production, and inflammatory responses.
• Cell Biology: Employed to induce apoptosis and study programmed cell death mechanisms in various cell lines.
• Pharmacology & Drug Discovery: Serves as a reference compound and a lead structure for developing novel SphK inhibitors for therapeutic applications.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in lipid metabolism and signal transduction.

Basic Information

Item	Detail
Product Name	N,n-Dimethylsphingosine
CAS No.	122314-67-4
Molecular Formula	C20H41NO2
Molecular Weight	327.55 g/mol
Synonyms	DMS; (2S,3R)-2-(Dimethylamino)-3-hydroxyoctadec-4-ene; N,N-Dimethyl-D-erythro-sphingosine; N,N-Dimethylsphingosine; (2S,3R,4E)-2-(Dimethylamino)-3-hydroxy-4-octadecene; Sphingosine, N,N-dimethyl-; SKI II (Note: SKI II is a closely related analog, often used interchangeably in literature searches)
EINECS	Contact for details

Quality Control

Our N,n-Dimethylsphingosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.