Description

(-)-Trichostatin A CAS NO 122292-85-7 is a potent and highly specific histone deacetylase (HDAC) inhibitor, widely recognized as a critical research tool in epigenetics and molecular biology. Its primary value lies in its ability to induce hyperacetylation of histones, leading to chromatin remodeling and altered gene expression, which is fundamental for studying cellular differentiation, proliferation, and apoptosis. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on oncology, neurology, and epigenetic drug discovery.

Application

• Epigenetic Research: A standard reagent for studying histone acetylation, chromatin structure, and gene regulation mechanisms.
• Cancer Biology Studies: Used to investigate the role of HDACs in tumorigenesis and to evaluate potential anti-cancer therapies.
• Stem Cell Research: Employed to modulate cell differentiation and reprogramming by altering epigenetic markers.
• Neurological Disease Models: Applied in research on neurodegenerative conditions where epigenetic dysregulation is implicated.
• Biochemical Assay Development: Serves as a positive control and reference standard in HDAC inhibitor screening assays.
• Pharmaceutical R&D: Used as a lead compound or molecular probe in the discovery and development of novel epigenetic therapeutics.

Basic Information

Product Name	(-)-Trichostatin A
CAS No.	122292-85-7
Molecular Formula	C17H22N2O3
Molecular Weight	302.37 g/mol
Synonyms	Trichostatin A; TSA; (R)-Trichostatin A; (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; (-)-TSA; HDAC Inhibitor VIII; NSC 563584; Antibiotic Trichostatin A
EINECS	Contact for details

Quality Control

Our (-)-Trichostatin A is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable and reproducible performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated and under inert atmosphere if necessary. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%
Biological Activity (HDAC Inhibition)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.