Description

17,20-Dimethylisocarbacyclin CAS NO 122168-74-5 is a synthetic analog of prostacyclin, a potent vasodilator and inhibitor of platelet aggregation. This compound is valued for its enhanced metabolic stability and targeted biological activity compared to its parent molecule. It serves as a critical pharmaceutical intermediate and research chemical for the development of novel therapeutics targeting cardiovascular diseases, pulmonary hypertension, and thrombosis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced prostaglandin-based drugs.
• Cardiovascular Research: Used in preclinical studies to investigate vasodilation, platelet function, and vascular remodeling.
• Pulmonary Hypertension Models: Employed as a reference compound in developing and testing new treatments for pulmonary arterial hypertension (PAH).
• Biochemical Research: A tool compound for studying prostacyclin (IP) receptor signaling pathways and interactions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	17,20-Dimethylisocarbacyclin
CAS No.	122168-74-5
Molecular Formula	C23H38O4
Molecular Weight	378.55 g/mol
Synonyms	17,20-Dimethylisocarbacyclin; 9-Deoxy-9α,11α-epoxy-15α,16α-methylene-17,20-dimethylprostaglandin I2; Isocarbacyclin 17,20-dimethyl derivative; 15α,16α-Methylene-17,20-dimethyl-9-deoxy-9α,11α-epoxy-PGI2; 17,20-Dimethyl PGI2 analog
EINECS	Contact for details

Quality Control

Our 17,20-Dimethylisocarbacyclin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP intermediate requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.