Description

1'-o-Acetylpaxilline is a chemically modified derivative of the tremorgenic mycotoxin paxilline. This compound is of significant interest in biochemical and pharmacological research as a potent and selective inhibitor of high-conductance calcium-activated potassium (BK) channels. It serves as a critical research tool for neuroscientists and pharmacologists studying ion channel function, neuronal excitability, and smooth muscle contractility. The high-purity material is essential for ensuring reproducible and reliable experimental results in both academic and industrial R&D settings.

Application

• Neuroscience Research: As a selective BK channel blocker for studying the role of these channels in neuronal signaling, neurotransmitter release, and action potential shaping.
• Cardiovascular Pharmacology: Investigation of BK channel function in vascular smooth muscle tone and blood pressure regulation.
• Toxicology Studies: Used as a reference standard or analytical standard in the study of tremorgenic mycotoxins and their metabolic pathways.
• Ion Channel Screening: A key pharmacological tool in high-throughput screening assays to identify novel modulators of ion channel activity.
• Biochemical Mechanism Studies: Elucidation of structure-activity relationships (SAR) for paxilline derivatives and their interaction with the BK channel pore.
• Cell Physiology: Research into the role of BK channels in cell proliferation, migration, and secretion processes.

Basic Information

Product Name	1'-o-Acetylpaxilline
CAS No.	121998-08-1
Molecular Formula	C27H33NO5
Molecular Weight	451.56 g/mol
Synonyms	1'-O-Acetylpaxilline; 1'-Acetylpaxilline; 3-[(1S,4aS,4bR,6aS,10aS,10bS,12aS)-1-Acetyloxy-1,4b,6a,10a,10b,12a-hexahydro-4a,9-dihydroxy-7,10-dimethyl-3H-2,8-dioxa-7-azacyclopenta[5,6]naphtho[1,2-f]azulen-3-yl]-2-methyl-2-butenoic acid methyl ester; Acetylpaxilline; Paxilline 1'-acetate
EINECS	Contact for details

Quality Control

Our 1'-o-Acetylpaxilline is manufactured under strict quality control protocols to ensure the highest standards of purity and consistency required for research applications. Each batch is thoroughly characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.