Description

9,11-Dimethylmethano-11,12-Methano-16-(3-Iodo-4-Azidophenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2 is a sophisticated synthetic analog of thromboxane A2, designed for advanced biochemical and pharmacological research. Its complex structure, featuring an iodo-azidophenyl moiety, makes it a critical tool compound for studying thromboxane receptor interactions, signal transduction pathways, and for potential use in photoaffinity labeling studies. This high-purity intermediate is essential for researchers and developers in pharmaceutical R&D, medicinal chemistry, and biochemical assay development who require precise, well-characterized molecules for target validation and probe design.

Application

• Pharmacological Research: As a potent thromboxane A2 receptor (TP receptor) agonist/antagonist analog for investigating cardiovascular, pulmonary, and renal pathophysiology.
• Medicinal Chemistry & Drug Discovery: Serving as a key synthetic intermediate or a reference standard in the development of novel anti-thrombotic and anti-inflammatory agents.
• Biochemical Probe Development: Utilization of the azido and iodo functional groups for photoaffinity labeling, cross-linking experiments, and mapping receptor binding sites.
• Signal Transduction Studies: Investigating the role of thromboxane A2 in platelet aggregation, vasoconstriction, and smooth muscle cell proliferation.
• Reference Standard: For use in analytical methods (HPLC, LC-MS) to qualify and quantify related compounds in research samples or complex matrices.
• Academic & Institutional Research: Fundamental studies in biochemistry and molecular biology focused on eicosanoid metabolism and receptor biology.

Basic Information

Product Name	9,11-Dimethylmethano-11,12-Methano-16-(3-Iodo-4-Azidophenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2
CAS No.	121951-69-7
Molecular Formula	C24H27IN4O4
Molecular Weight	562.40 g/mol
Synonyms	13-Aza-15-tetranor Thromboxane A2 analog; 16-(3-Iodo-4-azidophenyl)-13,14-dihydro-13-aza-15-tetranor TXA2; 9,11-Dimethylmethano-11,12-methano-16-(3-iodo-4-azidophenyl)-13,14-dihydro-13-aza-15-tetranorthromboxane A2; Iodo-Azido Thromboxane A2 Analog; TXA2 Photoaffinity Labeling Analog; TP Receptor Probe; SQ 28,668 derivative (related compound).
EINECS	Contact for details

Quality Control

Our 9,11-Dimethylmethano-11,12-Methano-16-(3-Iodo-4-Azidophenyl)-13,14-Dihydro-13-Aza-15-Tetranorthromboxane A2 is manufactured under strict quality management protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), identity confirmation (by NMR, MS), and other relevant parameters are provided to guarantee material integrity for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic and strictly light-sensitive nature, the material should be handled in a controlled environment with minimal exposure to moisture and light. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0% (Area Percent)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.