Description

Pka Inhibitor Fragment (6-22) Amide is a synthetic peptide fragment designed for biochemical and pharmacological research. This compound serves as a critical tool molecule for studying protein kinase A (PKA) signaling pathways and developing novel therapeutic inhibitors. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and signal transduction studies. The product is supplied as a high-purity material suitable for in vitro and cell-based assay applications.

Application

• Biochemical Research: Used as a reference standard and substrate analog in enzymatic assays to study PKA activity and inhibition kinetics.
• Drug Discovery: Serves as a key intermediate or pharmacophore model for the design and screening of novel PKA-targeted therapeutic agents.
• Signal Transduction Studies: Employed in cellular models to investigate the role of PKA in various physiological and pathological processes.
• Proteomics & Peptide Chemistry: Acts as a building block or template for synthesizing longer peptide sequences or conjugates for structural-activity relationship (SAR) studies.
• Academic Research: Utilized in university and institutional labs for fundamental research into cAMP-dependent protein kinase mechanisms.

Basic Information

Product Name	Pka Inhibitor Fragment (6-22) Amide
CAS No.	121932-06-7
Molecular Formula	C78H122N24O19
Molecular Weight	1651.9 g/mol
Synonyms	PKI(6-22) Amide; PKA Inhibitor (6-22) Amide; Protein Kinase A Inhibitor Fragment (6-22) Amide; cAMP-dependent Protein Kinase Inhibitor (6-22) Amide; TTYADFIASGRTGRRNAIHD-NH2; H-Tyr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-NH2; PKI Peptide (6-22) Amide
EINECS	Contact for details

Quality Control

Our Pka Inhibitor Fragment (6-22) Amide is manufactured under strict quality protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 8.0%
Solubility	Soluble in water or aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.