Description

(-)-Mk-801 Maleate is a high-purity, selective, and potent non-competitive antagonist of the NMDA receptor. This compound is a critical research-grade chemical essential for advanced neuroscience and pharmacological studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies investigating neurological pathways, excitotoxicity, and potential neuroprotective agents.

Application

• Neuroscience Research: A fundamental tool for studying the role of NMDA receptors in synaptic plasticity, learning, memory, and neuronal signaling.
• Pharmacological Studies: Used as a reference standard in the development and screening of novel neuroprotective drugs and CNS-active compounds.
• Biochemical Assays: Serves as a key reagent in receptor binding assays and functional studies to characterize NMDA receptor activity and inhibition.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on understanding excitatory neurotransmission and related disorders.
• Preclinical Investigation: Employed in animal model studies to explore mechanisms of ischemia, neurodegenerative diseases, and psychiatric conditions.

Basic Information

Product Name	(-)-Mk-801 Maleate
CAS No.	121917-57-5
Molecular Formula	C16H15N·C4H4O4
Molecular Weight	337.37 g/mol
Synonyms	(5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate; Dizocilpine maleate; MK-801 hydrogen maleate; (5R,10S)-(+)-MK-801 maleate; (-)-MK-801 maleate salt; (+)-MK-801 maleate; Dizocilpine hydrogen maleate
EINECS	Contact for details

Quality Control

Our (-)-Mk-801 Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.