Description

Valspodar is a potent, third-generation P-glycoprotein (P-gp) inhibitor and multidrug resistance (MDR) modulator used in pharmaceutical research and development. Its core value lies in its ability to enhance the efficacy of chemotherapeutic agents by overcoming tumor cell resistance mechanisms. This makes it a critical research compound for oncology studies, particularly in investigating combination therapies and improving drug delivery. Researchers and pharmaceutical developers in the fields of experimental oncology and pharmacokinetics are the primary users of this high-purity chemical.

Application

• Oncology Research: As a key tool compound for studying P-glycoprotein-mediated multidrug resistance in various cancer cell lines and in vivo models.
• Pharmacokinetic Studies: Used to investigate the absorption, distribution, and bioavailability of co-administered chemotherapeutic drugs.
• Drug Delivery Enhancement: Research into formulating combination therapies where Valspodar is used to potentiate the effect of other anticancer agents.
• Biochemical Assay Development: Serves as a reference standard and active agent in assays designed to screen for MDR reversal activity.
• Mechanism of Action Studies: Fundamental research into the structure and function of drug efflux pumps and cellular defense mechanisms.

Basic Information

Product Name	Valspodar
CAS No.	121584-18-7
Molecular Formula	C₆₃H₈₈N₈O₁₂
Molecular Weight	1141.4 g/mol
Synonyms	PSC 833; SDZ PSC 833; Valspodar; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-[(2R)-Butan-2-yl]-33-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]propyl]-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-12,15-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-15-carboxylic acid; Cyclosporin D, 3'-keto-Bmt-1-[N-methyl-D-valine]-; NSC 694217
EINECS	Contact for details

Quality Control

Our Valspodar is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.