Description

10,10-Difluorothromboxane A2 is a fluorinated analog of the potent prostanoid thromboxane A2, a key mediator in platelet aggregation and vasoconstriction. This compound is a critical research-grade biochemical tool used to study thromboxane receptor (TP) pharmacology and signaling pathways with enhanced metabolic stability. It is essential for pharmaceutical R&D, academic research, and biotechnology laboratories focused on cardiovascular disease, thrombosis, and inflammation.

Application

• Pharmacological Research: Acts as a stable agonist or reference standard for investigating thromboxane A2 (TP) receptor function and downstream signaling cascades.
• Cardiovascular Disease Models: Used in *in vitro* and *in vivo* studies to model platelet activation, vasoconstriction, and related pathologies.
• Drug Discovery & Development: Serves as a key intermediate or reference compound in the synthesis and screening of novel TP receptor antagonists and modulators.
• Biochemical Assay Development: Employed as a calibrant or control in developing high-throughput screening (HTS) assays and analytical methods (e.g., LC-MS, ELISA).
• Metabolic Stability Studies: The difluoro modification makes it a valuable probe for studying the metabolism and degradation pathways of eicosanoids.
• Academic & Institutional Research: Supports fundamental research in biochemistry, physiology, and medicinal chemistry related to the arachidonic acid cascade.

Basic Information

Product Name	10,10-Difluorothromboxane A2
CAS No.	121573-36-2
Molecular Formula	C21H32F2O6
Molecular Weight	418.48 g/mol
Synonyms	10,10-Difluoro-TXA2; 10,10-Difluoro-thromboxane A2; (5Z,9α,11α,13E,15S)-9,11-Epoxy-15-hydroxythromboxa-5,13-dien-1-oic acid, 10,10-difluoro-; Difluorothromboxane A2; TXA2 difluoro analog; Thromboxane A2, 10,10-difluoro-
EINECS	Contact for details

Quality Control

Our high-purity 10,10-Difluorothromboxane A2 is manufactured under controlled conditions to ensure batch-to-batch consistency for critical research applications. Each lot undergoes rigorous analytical characterization, including HPLC for purity and NMR/LC-MS for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment to support your quality and compliance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.