Description

Hormaomycin is a naturally occurring cyclic depsipeptide antibiotic isolated from Streptomyces strains, recognized for its potent and selective inhibition of bacterial protein synthesis via binding to the 50S ribosomal subunit. It serves as a high-value research tool in antimicrobial mechanism studies, ribosome structural biology, and novel antibiotic discovery pipelines. Researchers in pharmaceutical R&D, academic microbiology labs, and contract research organizations (CROs) rely on Hormaomycin CAS NO 121548-21-8 for target validation, resistance profiling, and structure–activity relationship (SAR) investigations.

Application

• Antibiotic mode-of-action studies targeting the bacterial 50S ribosomal subunit
• Structural biology research using cryo-electron microscopy (cryo-EM) and X-ray crystallography of ribosome–antibiotic complexes
• Lead compound screening and optimization in early-stage antibacterial drug discovery
• In vitro assessment of cross-resistance patterns among macrolide-, lincosamide-, and streptogramin-class antibiotics (MLSB phenotype)
• Development of radiolabeled or fluorescently tagged analogues for cellular uptake and localization studies
• Quality control reference standard for analytical method development (HPLC, LC-MS)
• Microbiological assay standard for potency determination of related ribosomal inhibitors
• Teaching and training material in advanced medicinal chemistry and molecular pharmacology curricula

Basic Information

Product Name	Hormaomycin
CAS No.	121548-21-8
Molecular Formula	C53H79N13O16
Molecular Weight	1174.27 g/mol
Synonyms	Hormaomycin; Hormaomycin A; Antibiotic K-252c; K-252c; NSC-632492; CID 6437282; SCHEMBL11452932; BDBM50247232; UNII-7Z5JQ8W5XN; CHEMBL4296462
EINECS	Not listed (EC number not assigned)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of Hormaomycin are tested per validated methods for identity (IR, HPLC retention time, MS), assay (HPLC), related substances (HPLC), residual solvents (GC), and heavy metals (USP <231>). Testing aligns with ACS Reagent Grade and EP 11.0 specifications where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (argon or nitrogen) to prevent degradation. Keep desiccated; avoid exposure to ambient humidity and oxygen.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	[M+H]+ m/z 1175.2 ± 0.5 (C53H80N13O16)
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Water (KF)	≤ 5.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.