Description

4-(Trifluoromethyl)Pyridine-2-Thiol CAS NO 121307-79-7 is a high-value organofluorine building block characterized by its reactive thiol and electron-deficient pyridine ring. This compound matters for its unique ability to introduce the trifluoromethylpyridine moiety into complex molecules, a key strategy for modulating lipophilicity, metabolic stability, and binding affinity. Pharmaceutical, agrochemical, and advanced material researchers need it for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical synthon for creating active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for specialized ligands in transition metal catalysis, enabling novel synthetic transformations.
• Material Science: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials requiring specific fluorine-based properties.
• Chemical Research: A versatile reagent for heterocyclic and medicinal chemistry research, facilitating structure-activity relationship (SAR) studies.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-2-Thiol
CAS No.	121307-79-7
Molecular Formula	C6H4F3NS
Molecular Weight	179.16 g/mol
Synonyms	2-Mercapto-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-pyridinethiol; 2-Pyridinethiol, 4-(trifluoromethyl)-; 4-Trifluoromethylpyridine-2-thiol; 2-Thiol-4-trifluoromethylpyridine; 4-(Trifluoromethyl)-2-mercaptopyridine; 2-Mercapto-4-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.