Description

Calphostin C is a potent, cell-permeable, and highly specific inhibitor of protein kinase C (PKC), originally isolated from the fungus *Cladosporium cladosporioides*. This compound is a critical research tool for studying intracellular signaling pathways, particularly those mediated by the PKC enzyme family, which plays a pivotal role in cell proliferation, differentiation, and apoptosis. It is essential for researchers and developers in pharmaceutical R&D, academic biochemistry, and cell biology laboratories investigating cancer mechanisms, neurological disorders, and cardiovascular diseases.

Application

• Biochemical Research: A fundamental tool for elucidating the role of Protein Kinase C (PKC) isoforms in cellular signal transduction pathways.
• Oncology Studies: Used to investigate PKC's involvement in tumor cell proliferation, survival, and metastasis, aiding in the discovery of novel anticancer targets.
• Neuroscience Research: Applied in studies of neuroinflammation, neurodegeneration, and synaptic plasticity where PKC activity is a key modulator.
• Cardiovascular Research: Employed to study PKC signaling in cardiac hypertrophy, heart failure, and vascular smooth muscle cell function.
• Pharmacology Screening: Serves as a reference standard and positive control in high-throughput screening assays for identifying new PKC inhibitors.
• Cell Biology: Used to manipulate and understand PKC-dependent processes in cell culture models, including differentiation and apoptosis.

Basic Information

Product Name	Calphostin C
CAS No.	121263-19-2
Molecular Formula	C44H40O12
Molecular Weight	760.79 g/mol
Synonyms	UCN-1028C; Calphostin C (UCN-1028C); 4,10-Dihydroxy-2-methoxy-7,8,13,14-tetrahydroxy-3,11-dioxo-6-pentyl-1H,3H,11H-benzofuro[3,2-a]xanthen-1-yl 3,5-dihydroxy-2,4-dimethylbenzoate; PKC Inhibitor Calphostin C; Benzofuroxanthen-1-yl benzoate derivative
EINECS	Contact for details

Quality Control

Our Calphostin C is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and potency is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its strictly light-sensitive nature, handling should be performed under subdued light or in amber glass vials to maintain stability and potency. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Dark green to brown solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol
Loss on Drying	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.