Description

Sn-38 Glucuronide is a key metabolite and prodrug derivative of the potent topoisomerase I inhibitor, SN-38. This compound is of significant interest in pharmaceutical research and development, particularly for its role in targeted drug delivery strategies. It is primarily utilized by researchers and manufacturers in the oncology and pharmaceutical sectors for the development of advanced therapeutics and analytical standards.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced prodrugs and antibody-drug conjugates (ADCs) for targeted cancer therapy.
• Metabolite Reference Standard: Used as a high-purity analytical standard in bioanalytical laboratories for pharmacokinetic and metabolic studies of irinotecan and related compounds.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate glucuronidation pathways, drug metabolism, and enzyme kinetics.
• Drug Discovery & Development: Serves as a vital tool for evaluating the efficacy, safety, and metabolic profile of novel camptothecin analogs.
• Quality Control: Essential component for the development and validation of HPLC, LC-MS, and other analytical methods in pharmaceutical quality assurance.

Basic Information

Product Name	Sn-38 Glucuronide
CAS No.	121080-63-5
Molecular Formula	C34H36N4O11
Molecular Weight	676.67 g/mol
Synonyms	7-Ethyl-10-hydroxycamptothecin glucuronide; SN-38 Glucuronide; 10-Hydroxy-7-ethylcamptothecin glucuronide; (20S)-7-Ethyl-10-hydroxycamptothecin O-β-D-glucopyranosiduronic acid; SN-38G; SN38 Glucuronide; CPT-11 active metabolite glucuronide
EINECS	Contact for details

Quality Control

Our Sn-38 Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.