Description

1-(Difluoronitromethyl)-2-Fluorobenzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both difluoronitromethyl and fluorine substituents, makes it a valuable precursor for introducing fluorinated functional groups into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where fluorination enhances biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and advanced materials with specific electronic or surface properties.
• Fluorination Chemistry: Acts as a versatile reagent in methodologies for the selective introduction of difluoronitromethyl groups into complex organic frameworks.
• Ligand and Catalyst Development: Employed in the synthesis of novel fluorinated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	1-(Difluoronitromethyl)-2-Fluorobenzene
CAS No.	121058-19-3
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	2-Fluoro-α,α-difluoronitrotoluene; 2-Fluorobenzylidene difluoride, nitro-; 1-(Difluoronitromethyl)-2-fluorobenzene; α,α-Difluoro-2-fluorophenylnitromethane; (Difluoronitromethyl)fluorobenzene; o-Fluoro-α,α-difluoronitrotoluene; 2-Fluoro-α,α-difluoronitrobenzyl
EINECS	Contact for details

Quality Control

Our 1-(Difluoronitromethyl)-2-Fluorobenzene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality system supports development from research quantities to commercial scale.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the reactive nitro and fluoride groups, store separately from strong bases, reducing agents, and combustible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.